Henriette Kirchner

Dr. Henriette Kirchner

Center of Brain, Behavior and Metabolism
Medical Department 1
University of Lübeck

Focus of work

Our group studies the association between epigenetic modifications and the development of obesity and type 2 diabetes. As the liver is a key gluco-regulatory organ we mainly focus on alterations in hepatic DNA-methylation and microRNAs and their link to metabolic diseases. Using biopsies from obese and/or diabetic patients in combination with mouse models of obesity we aim to identify the triggers of epigentic remodeling, the mechanisms that consequently altered gene expression, and therapies to reverse pathological DNA methylation and microRNAs to the physiological state.